The Science of Predictive Human Biology

Alto Predict is focused on the challenge of predicting human outcomes to drug and chemical exposures

Transforming Drug Discovery Through Human-Based Phenotypic Profiling

Developing Frameworks For Integrating Information To Understand Human Disease

In the News

The Alto Predict Project

The Alto Predict Project is an open science project to organize our knowledge of the causal mechanisms underlying drug effects on human outcomes at the cell and pathway level. This project is inspired by the AOP framework approach being developed…

Phenotypic Screening – Advancing the Science

This new article in DDW adds to some very good recent perspectives on phenotypic drug discovery (PDD) from the pharma industry in NRDD and ADDT (see additional articles and further commentary here,  here and here) that lay out the current situation,…
Mouse Vs Man

Mouse Vs Man - The Importance of Human-Based Approaches in Biomedical Research

Incorporating more relevant, human-based approaches (in vitro and in silico) in biomedical and toxicological research is a hot topic these days (see recent conferences organized by SOT, BioMed21, WC10, SACATM, and the ASCCT). While those of…

ASCCT 2017 Conference in Gaithersburg

For researchers interested in the modernization of chemical and drug safety testing, registration is open for the 6th Annual ASCCT Meeting taking place September 21-22, 2017 in Gaithersburg, MD. This year’s conference topics include: …
BioMed21 2017

BioMed21 Workshop

A Human Pathway-based Approach to Disease and Medicine is the theme of the BioMed21 workshop being held June 26-27, 2017 in Bethesda MD and co-organized by the National Toxicology Program and the Human Toxicology Project Consortium. The workshop…

BioMAP Systems at SOT 2017

Join the BioMAP team from DiscoverX at the Society of Toxicology’s 56th Annual Meeting and ToxExpo, March 12-16, 2017 in Baltimore, MD.  Visit our booth #406 or see us at the following events: Exhibitor Hosted Session on Discovery of…



Phenotypic Profiling for Translational Drug Research

Selection, use, and interpretation of in vitro assays to support drug discovery programs, from early discovery through development into clinical and post-marketing studies.

Drug and Toxicity Mechanisms

Research and analysis of drug mechanisms of action relevant to clinical outcomes. Expertise in drug and chemical toxicity mechanisms and design of mitigation strategies.

Data Analysis and Interpretation

Expertise in the analysis and interpretation of phenotypic assay data and the integration of diverse data types and information sources into decision frameworks.