Making Assays FAIR
Many drugs can cause adverse effects on the cardiovascular system. Oncology drugs including targeted kinase inhibitors are particularly problematic. Cardiovascular toxicities present in the clinic as high blood pressure, cardiac…
The ToxCast program of the US EPA was initiated over a decade ago. Its goal was to find rapid and efficient methods to prioritize thousands of chemicals for potential human health…
Excipients are the “fillers” in formulated drugs. They are included to ensure long term storage, stabilize or promote delivery of the active drug. Excipients are assumed by many to be…
Phenotypic assays using human cell types can help replace animal testing in drug discovery and product development. We can’t trust these assays, however, if we can’t explain why or why…