Making Assays FAIR
Biology and engineering – my favorite topic! Thank you to Vijay Pande and Derek Lowe for recent blog posts discussing the influence of engineering in biology research and drug discovery. I believe…
The recent failure of the IDO inhibitor epacadostat in combination with Merck’s pembrolizumab for immuno-oncology (IO) has been the subject of numerous reports and commentary (see here, here, here and Vinay Prasad’s epic twitter rant here). And now today…
Machine learning & artificial intelligence (AI) is the latest new new thing capturing interest in the pharmaceutical industry. Predicting patient responses from large data sets gathered by wearable devices or…
The Alto Predict Project is an open science project to organize our knowledge of the causal mechanisms underlying drug effects on human outcomes at the cell and pathway level. This…
This new article in DDW adds to some very good recent perspectives on phenotypic drug discovery (PDD) from the pharma industry in NRDD and ADDT (see additional articles and further…
Incorporating more relevant, human-based approaches (in vitro and in silico) in biomedical and toxicological research is a hot topic these days (see recent conferences organized by SOT, BioMed21, WC10, SACATM,…
In drug discovery and chemical safety research, validation lies at the heart of every assay, reagent and experiment. Validation is fundamental for life sciences research effectiveness and, according to Scannell and…
The recent re-launch of the Chemical Probes Portal, a community-led resource for chemical probe information, is a convenient time for reviewing best practices. Chemical probes are small molecules developed to selectively…
If phenotypic screening is driving innovation in drug discovery, network biology is the fuel. In phenotypic screening, compounds are tested for their functional effects on cellular responses in a target agnostic…
The selection of chemical matter to be used for screening is a major discussion topic for phenotypic drug discovery (PDD) researchers. At the recent Keystone Symposium on PDD, several talks were…